Vetoquinol Zylkene Calming Supplement, 450 mg for Dogs 33-132 lbs., Front Hover to Zoom

Vetoquinol Zylkene Calming Supplement, 450 mg for Dogs 33-132 lbs.

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Key Benefits

  • Clinically proven to help relieve stress without drowsy side effects
  • Vet recommended to help pets cope with challenging situations like thunderstorms, car rides, separation, and more
  • Made with natural ingredients that are easy on sensitive stomachs with a lactose- and preservative-free formula
  • The only brand to contain alpha-casozepine, a naturally occurring milk protein found in cow’s milk


A pet’s life is full of new people, new situations, and new challenges. With Zylkene®, your pet can find balance when life gets stressful.

Zylkene is a behavior supplement that helps dogs and cats relax, adapt to new locations, or cope with challenging situations — without making them drowsy.

When to use Zylkene:

  • New places. Whether your pet is visiting the groomer, the vet, or moving to a new home with you, Zylkene can help them stay calm as they adjust to new environments without modifying their behavior or making them drowsy.
  • New situations. Fireworks, thunderstorms, and travel: few things are more stressful to your pets. That’s why Zylkene is the perfect supplement to help pets stay calm without sedation, which makes new situations easier for them — and for you.
  • New people. Is company coming over? Do you have a new baby in the house? With Zylkene, your pets can calmly adjust to new additions to the family — or just friends coming over to visit – without stressing out about it.

Zylkene can be given whole or opened at meal time and can be used for short- or long-term use. It’s the perfect supplement to help your pet face life’s challenges.

Ours is the only pet nutritional supplement to contain alpha-casozepine, a naturally calming, non-drowsy ingredient extracted from cow's milk. This safe alternative to sedatives can be used daily to promote a sense of calm in stressed dogs and cats.

Use Zylkene capsules as needed or daily for as long as your dog or cat needs calming support. We manufacture Zylkene right here in the USA, under strict pharmaceutical guidelines.

Although Zylkene contains alpha-casozepine extracted from cow's milk, it doesn't contain lactose. Lactose is a sugar found in cow's milk that can irritate the stomach. Simply give the capsules to your pet whole or break them open and mix with food.


Vetoquinol stands behind its products with a 100% sastifaction guarantee or your money back. Try it today!


Hydrolized milk protein (bovine) providing alpha-casozepine, FD&C blue #1 (capsule), hypromellose (capsule), magnesium stearate, maltodextrin, titanium dioxide (capsule)


Zylkene 450 mg is made for dogs 33 to 132 pounds.

33-65 lbs and under: 1 capsule/day
66-132 lbs: 2 capsules/day

Capsules can be administered orally as a single dose, whole or opened at meal time. Use as recommended by your veterinarian. Short-term use: Use Zylkene for 1–2 days before a planned event or change in environment. Some animals may need earlier administration (5–7 days).

Product Info

Zylkene 450 mg is available in 14-count blister packs, 30-count bottles, or 120-count bottles.

UPC 30ct: 850046480256